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Index > Protein center > CNR2(Gene name) > Human
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  • CNR2 (Gene name),
  • Cannabinoid receptor 2 (Protein name ),  CNR2_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    CNR2(CB2A;CB2B);
    Protein name:
    Cannabinoid receptor 2(CB-2;CB2;hCB2);
    Alternative:
    CX5;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis.
    Subcellular Location:
    Cell membrane Multi-pass membrane protein Cell projection dendrite Perikaryon Localizes to apical dendrite of pyramidal neurons.
    Protein Attributes:
    Sequence length:
    360
    Sequence:
    50:
    MEECWVTEIA | NGSKDGLDSN | PMKDYMILSG | PQKTAVAVLC | TLLGLLSALE | 
    100:
    NVAVLYLILS | SHQLRRKPSY | LFIGSLAGAD | FLASVVFACS | FVNFHVFHGV | 
    150:
    DSKAVFLLKI | GSVTMTFTAS | VGSLLLTAID | RYLCLRYPPS | YKALLTRGRA | 
    200:
    LVTLGIMWVL | SALVSYLPLM | GWTCCPRPCS | ELFPLIPNDY | LLSWLLFIAF | 
    250:
    LFSGIIYTYG | HVLWKAHQHV | ASLSGHQDRQ | VPGMARMRLD | VRLAKTLGLV | 
    300:
    LAVLLICWFP | VLALMAHSLA | TTLSDQVKKA | FAFCSMLCLI | NSMVNPVIYA | 
    350:
    LRSGEIRSSA | HHCLAHWKKC | VRGLGSEAKE | EAPRSSVTET | EADGKITPWP | 
    360:
    DSRDLDLSDC | 
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    SMR:
    MIM:
    Pfam:
    String:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human CB-2
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    E10714r
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    ELISA Kit for Human CB-2
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    E10714m
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    ELISA Kit for Human CB-2
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    E10714h
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    CLIA Kit for Human CB-2
    Cat.:
    U10714h
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    Packing:
    96T
    CLIA Kit for Human CB-2
    Cat.:
    U10714r
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    Packing:
    96T
    CLIA Kit for Human CB-2
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    U10714m
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human CB-2
    Cat.:
    P10714Rb-m
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human CB-2
    Cat.:
    P10714Rb-r
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human CB-2
    Cat.:
    P10714Rb-h
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human CB-2
    Monoclonal Antibody for Human CB-2
    Monoclonal Antibody for Human CB-2
    Protein for Human CB-2
    Protein for Human CB-2
    Protein for Human CB-2

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    Precision
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    Linearity
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    References
    1. 1.
      "Molecular characterization of a peripheral receptor for cannabinoids."
      Munro S. , Thomas K.L. , Abu-Shaar M.
      Nature365:61-65(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    2. 2.
      "Species differences in cannabinoid receptor 2 (CNR2 gene): identification of novel human and rodent CB2 isoforms, differential tissue expression and regulation by cannabinoid receptor ligands."
      Liu Q.-R. , Pan C.H. , Hishimoto A. , Li C.Y. , Xi Z.X. , Llorente-Berzal A. , Viveros M.P. , Ishiguro H. , Arinami T. , Onaivi E.S. , Uhl G.R.
      Genes Brain Behav.8:519-530(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY
      tissue: Spleen.
    3. 3.
      "Cannabinoid receptors and their genes."
      Bruess M. , Boenisch H.
      Submitted (2003-02) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]
      tissue: Blood.
    4. 4.
      "Isolation of complete coding sequence for cannabinoid receptor 2 (CNR2)."
      Warren C.N. , Aronstam R.S. , Sharma S.V.
      Submitted (2003-02) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    5. 5.
      "Amplification and cloning of human cannabinoid receptor 2 gene from Asiatic origin."
      Saravanan T. , Chugh A. , Kant R.
      Submitted (2005-11) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT TYR-316
      tissue: Blood.
    6. 6.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    8. 8.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANTS ARG-63 AND TYR-316
      tissue: Brain.
    9. 9.
      "Expression of central and peripheral cannabinoid receptors in human immune tissues and leukocyte subpopulations."
      Galiegue S. , Mary S. , Marchand J. , Dussossoy D. , Carriere D. , Carayon P. , Bouaboula M. , Shire D. , Le Fur G. , Casellas P.
      Eur. J. Biochem.232:54-61(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
    10. 10.
      "Regulation of peripheral cannabinoid receptor CB2 phosphorylation by the inverse agonist SR 144528. Implications for receptor biological responses."
      Bouaboula M. , Dussossoy D. , Casellas P.
      J. Biol. Chem.274:20397-20405(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-352;SUBCELLULAR LOCATION
    11. 11.
      "Role of a conserved lysine residue in the peripheral cannabinoid receptor (CB2): evidence for subtype specificity."
      Tao Q. , McAllister S.D. , Andreassi J. , Nowell K.W. , Cabral G.A. , Hurst D.P. , Bachtel K. , Ekman M.C. , Reggio P.H. , Abood M.E.
      Mol. Pharmacol.55:605-613(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;MUTAGENESIS OF LYS-109 AND SER-112
    12. 12.
      "Evidence that 2-arachidonoylglycerol but not N-palmitoylethanolamine or anandamide is the physiological ligand for the cannabinoid CB2 receptor. Comparison of the agonistic activities of various cannabinoid receptor ligands in HL-60 cells."
      Sugiura T. , Kondo S. , Kishimoto S. , Miyashita T. , Nakane S. , Kodaka T. , Suhara Y. , Takayama H. , Waku K.
      J. Biol. Chem.275:605-612(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION OF 2-ARACHIDONOYLGLYCEROL AS AN ENDOGENOUS LIGAND
    13. 13.
      "Presence and regulation of the endocannabinoid system in human dendritic cells."
      Matias I. , Pochard P. , Orlando P. , Salzet M. , Pestel J. , Di Marzo V.
      Eur. J. Biochem.269:3771-3778(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
    14. 14.
      "Absence of a conserved proline and presence of a conserved tyrosine in the CB2 cannabinoid receptor are crucial for its function."
      Song Z.H. , Feng W.
      FEBS Lett.531:290-294(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF LEU-201 AND TYR-207
    15. 15.
      "Effects of D3.49A, R3.50A, and A6.34E mutations on ligand binding and activation of the cannabinoid-2 (CB2) receptor."
      Feng W. , Song Z.H.
      Biochem. Pharmacol.65:1077-1085(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;MUTAGENESIS OF ASP-130; ARG-131 AND ALA-244
    16. 16.
      "2-arachidonoylglycerol induces the migration of HL-60 cells differentiated into macrophage-like cells and human peripheral blood monocytes through the cannabinoid CB2 receptor-dependent mechanism."
      Kishimoto S. , Gokoh M. , Oka S. , Muramatsu M. , Kajiwara T. , Waku K. , Sugiura T.
      J. Biol. Chem.278:24469-24475(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    17. 17.
      "Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors."
      Casanova M.L. , Blazquez C. , Martinez-Palacio J. , Villanueva C. , Fernandez-Acenero M.J. , Huffman J.W. , Jorcano J.L. , Guzman M.
      J. Clin. Invest.111:43-50(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
    18. 18.
      "Cannabinoid CB2 receptors and fatty acid amide hydrolase are selectively overexpressed in neuritic plaque-associated glia in Alzheimer's disease brains."
      Benito C. , Nunez E. , Tolon R.M. , Carrier E.J. , Rabano A. , Hillard C.J. , Romero J.
      J. Neurosci.23:11136-11141(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
    19. 19.
      "Cannabinoid CB2 receptors are expressed by perivascular microglial cells in the human brain: an immunohistochemical study."
      Nunez E. , Benito C. , Pazos M.R. , Barbachano A. , Fajardo O. , Gonzalez S. , Tolon R.M. , Romero J.
      Synapse53:208-213(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
    20. 20.
      "Cannabinoid receptor CB2 localisation and agonist-mediated inhibition of capsaicin responses in human sensory neurons."
      Anand U. , Otto W.R. , Sanchez-Herrera D. , Facer P. , Yiangou Y. , Korchev Y. , Birch R. , Benham C. , Bountra C. , Chessell I.P. , Anand P.
      Pain138:667-680(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY
    21. 21.
      "Structural biology of human cannabinoid receptor-2 helix 6 in membrane-mimetic environments."
      Tiburu E.K. , Tyukhtenko S. , Deshmukh L. , Vinogradova O. , Janero D.R. , Makriyannis A.
      Biochem. Biophys. Res. Commun.384:243-248(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 240-272
    22. 22.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ARG-63 AND TYR-316
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